Don't really think its the gambling that causes relationship breakdowns, its when partners or family members are kept in the dark or deceived, which breaks the trust that's so essential in any relationship. It's up to us to make informed decisions, to be self-aware of our behaviors, and to ensure we're not crossing lines that jeopardize our relationships and personal well-being.
Depending on the individual, no gambler can win consistently due to the successful use of game theory. In such cases or in bankruptcy after accepting constant losses people get depressed when gambling becomes addictive self-esteem stress can cause anxiety and depression and it affects family relationships because an addicted person loses control and breaks up relationships. If you use it compulsively or feel out of control it won't take long for things to go sour. They abandon all the important activities of life to gamble they only look for opportunities to gamble and immerse themselves in gambling. But a responsible gambler has no such influence as they are able to control everything.