I think it was a major blow for Sheffield this season and I believe Newcastle's winning record of scoring 8 goals will be very difficult for other teams including Manchester City to break throughout this season. I agree Newcastle will be very motivated from that win, but they have a game against Manchester City for the EFL Cup before the end of the month.
So far Newcastle have taken 10 points, but I believe they will probably not repeat the same form as last season by ending the season in the Champions League zone. Many people have doubts about Newcastle, but if they can improve their quality then of course Newcastle can compete for that too.
It may be difficult to win against Sheffield more than 8 goals, but it is not impossible for Man City or other top teams in EPL.