Arteta is responsible for Saka's injury because he always starts Bukayo Saka every match, and even after being kicked down in an Arsenal match against Tottenham, Arteta still starts him in Arsenal's last Premier League game against Bournemouth. I expect Arteta to rest Saka against Lense so that he will be fully rested to face Manchester City, but he risks the player, and the player ends up getting injured and won't be able to face Arsenal's greatest rival Manchester City.
There is still hope for Arsenal to win the match since Manchester City also have injured players in the squad, and Arsenal can manage to play with Nelson and Trossard with either Jesus or Nketiah at the top, and they can get a result since their midfield is complete.
This is a disadvantage for Arsenal in the upcoming match because Saka is one of the most important players in their squad. However, because Arteta did not make an early rotation, the big impact was the loss of Saka due to the injury he suffered when facing Lens. The Arsenal vs Manchester City match is quite a crucial match for both of them because both teams have injured players so it is believed that matches will be difficult to predict in this week's match. For Pep Guardiola, they will try hard to get back to winning ways after losing to Wolves the previous week.
Arsenal will probably take advantage of the situation in this match with the support of their supporters because this match will take place at the Emirates stadium. Apart from that, if you look at the temporary standings table, of course the final result of this match will make quite a big difference to their ranking this week. If Manchester City manages to win then they are quite safe at the top of the standings. But if they lose, there is an opportunity for Liverpool and Tottenham to move their ranking.