Yes, the Saka injury will seriously affect the team's performances, but even if Saka is there, I am not sure maybe Arsenal can beat Manchester City because Arsenal is not better than Manchester City. But let's just see what will happen this weekend. Maybe we will get a surprise result that goes against the record of many seasons. I don't think Arsenal have been able to defeat Manchester City in the league for over seven years now; even though it happened, I don't think it will be up to two times. So even in their next game, I can't say Arsenal will win, but if possible, they can play a draw.
You never could tell, maybe they may stand chance of doing better if saka was among the squad to play against City, however city are currently better than Arsenal when it comes to their performance this season, the only thing Arsenal are better than then with is the fact that they're still unbeaten in the league, however Arsenal had also had good performance so far and if they hadn't draw 2 of they games they would've been above City with like 3 points ahead.
Well If im to pick a side I'll go with City cause the got a better squad than Arsenal and moreover Arsenal would be without their star players well I think both teams would score the match might end with a 1-2 scores since Manchester City are the favorites to win the game.