Usually Dembele and Kolo Muani should be able to assist him a lot. If they are all in their best form they can be one of the best attack lines in Europe. But it is easy to anticipate that they will lack consistency. Dembele has never managed to be consistent for more than two months I believe and Kolo Muani has played amazing in Frankfurt, but still owes the proof how he will be doing over the course of a whole season in a club like PSG. The league shouldn't be a problem for him, that is nothing new, but the Champions League as far as I know is new to him and he was pretty bad last game.
What happens for PSG's attack line is like prioritizing Muani and the conditions are reversed where Muani is the target man and the role of Mbappe and Dembele must be able to provide good money service for Muani.
It was seen in the match when PSG lost badly to Newcastle in the Champions League continued where PSG applied an unusual strategy by giving space to Muani as a targetman but funnily enough giving more effort to Mbappe and Dembele behind them.
This did not go according to plan especially when looking at Mbappe who did not seem to be able to do much in this match because he was not too free with his position.
Enrique should be able to give more proportions because if you look at the current conditions it is a little complicated if you try some new schemes where Mbappe is used to 4-3-3.