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Sevilla is the home team, and it will be very difficult for Arsenal to play this match away. But before this match, Sevilla will have a very difficult match in La Liga with Real Madrid, so Arsenal can count on the fact that Sevilla can spend a lot of effort in this match, although perhaps for Sevilla in this case the Champions League match will be a priority. Before the match with Sevilla, Arsenal will face Chelsea, perhaps not the most difficult opponent, but in recent matches they have begun to play better.
away matches will always be a scary match for any team, even Arsenal will definitely have a little difficulty beating Sevilla but Arteta hope is to at least end in a draw to get additional points rather than losing against Sevilla.
I slightly disagree with your statement about Sevilla going to compete in the domestic league using up all their players and it not be that easy because Diego Alonso will arrange for second tier players to play in domestic league matches or the main players will not appear in the match. so Sevilla will prioritize UCL matches over domestic league matches and rest key players.
and conversely Arsenal will also compete in the domestic league but of course Arteta has a way of not spending too much energy and doing the same thing as Sevilla.
so domestic league matches will not affect performance in the UCL because every coach has thought about maintaining the performance of his players.