Sevilla don't often lose at home, although Arsenal are a very strong club at the moment. But I don't think Arsenal will necessarily win. I think this match could be a draw. Sevilla drew at home against group leader Lens, and Arsenal lost away to them. I think it's not all bad for Sevilla, although of course Arsenal are favourites.
Well, IMO, Sevilla's current position is very doubtful. the reason is, they have just changed coaches. Diego Alonso's first debut with Sevilla immediately featured a tough match versus Real Madrid. after that, they will host Arsenal in the Champions League group phase. As for the home games they played, they only won twice and that was against Las Pamas and Almeria. and when they hosted Lens, they only got a draw. It is not an easy matter for Sevilla's new coach to bring his team to appear immediately with a neat and impressive performance, a strong bond and chemistry will be needed to achieve the desired system. Therefore, it is not easy for Diego Alonso to bring his team and provide resistance against Real Madrid in La Liga and Arsenal in the Champions League.
On the other hand, Arteta needs full points to ensure his team is safe in the group phase when they visit Sevilla. The defeat against Lens on matchday 2 means that Arteta will anticipate that it will not happen again. After all, based on the quality of Arsenal's players, they are above Sevilla. Also, a win against City will provide strong encouragement and motivation to perform better in the next matches. Well, what's unique about football is that it's difficult to predict accurately. although, Arsenal is the more favorite team.
With the performances we've seen from both Sevilla and Arsenal this season, I'm very doubtful Sevilla is gonna progress out of the group ahead of Arsenal.
However, Sevilla seem to have a good record against English teams and that's why Arsenal has to play in their full strength in the double header games they have against the Spanish club in they UEFA Champions League competition. Sevilla I think doesn't have much to lose because if they should exit the UEFA Champions League competition, they'll be playing in the UEFA Europa League, a competition that they're are the most successful club in. So it's a very dicey encounter between the two clubs but I expect Arsenal to come out victorious in those two games.