Kevin De Bruyne is one of the most valuable players for Manchester City without doubt. His absence due to injury is really unlucky for them as well. However I don't think this would affect them deeply anyway. Because they are still one of the strongest teams in Europe now. They are full of world stars playing in coherence together.
It definitely had an impact and there had to be other options for Manchester City when De Bruyne was absent from their squad for a long time because they struggled to control their attacks and their ball flow became unstable.
The presence of players like Rodri can be an option, it's just that at this time Rodri is also still receiving punishment for card accumulation which we know that he still needs at least 1 more match for his sentence to be completed.
This is clearly inconvenient because the absence of KDB and Rodri makes their 2 matches lose points but for the championship problem it is clear they are still favorites because this will only have an impact for a few matches not as a whole.