The sad thing for Barcelona is about their next games where they don't have two effective players Frankie De Jong and Lewandoski.
De Jong got injured in the game they had against Celta de Vigo and that's why his situation for the next three games and even for the game against Real Madrid is not clear yet.
Also, Lewandoski got injured in the Champions League against Porto and he is still injured.
This can be a pain for Xavi to find an alternative strategy and play without both palyer against a team like Real Madrid.

Moreover, there is not much time for them to fully recover and also, the opponents that Barcelona will face in the next match cannot be said to be easy. So yes, it will be difficult for Xavi to make the right rotation for Barcelona in such a short time, and also playing against a team that is not easy. If so, then I think it is quite clear that there is no chance of winning for Barcelona for the El Clasico match later. Although indeed, I also realize that Barcelona still has other players who might still be reliable. But unfortunately, at this moment Real Madrid has a better situation and condition than Barcelona of course.