Drake’s curse? Not sure about that. I wouldn’t see this loss or even his total losses as a curse.
He losses his bets sometimes just like any other person who gambles. Perhaps what would seem remarkable in this case is the amount of money he uses to play. I think it’s pretty obvious to everyone that the higher the bet, the higher the amount to be won. Drake, having a considerably high net worth, is a high stake gambler and he knows the risks involved. This isn’t his first rodeo.

I don’t have much to say about this loss. He probably wouldn’t lose any sleep over this loss so why should anyone?
Amongst his other wins, he had won 2.7 million when he had bet on Israel Adesanya. There is no Drakes Curse.