You can profit on both sides, depending on which you desire. However, it is preferable to utilize usdt pair over btc pair because usdt is a stable coin and you are just dependent on the price of ETH, whereas btc pair requires you to consider not only eth but also btc. So, for me, it's a lot of hassle, very unpredictable, and has a poor profit potential compared to the USDT pair because I believe in Bitcoin's dominance. If you're familiar with successful crypto traders, you'll notice that they frequently use the USDT pair, but still up to your preference.