De Bruyne probably will be absense until end of this year but if Rodri can be played after suspension i think that's a good news because he can make Manchester City midfield sides will be more solid and indeed as defending champion recently Manchester City performance a bit decline but last week they can able to bounce back by beating Brighton and on that match Haaland was return to scored goal and for Manchester United they still faced some problem that some of their players good injured but they are in the good shape after gets 3 winning streak in all competitions
I haven't check the odds yet but i will assume Manchester United status as underdog but last season Manchester United has been able to beat Manchester City at Old Trafford so it's not impossible for them to repeat that result again moreover Manchester United players in the good mentally after gets the winning result from Copenhagen and the players just like Maguire or Onana was displayed impressive performance on that match and although it's hard but i think Manchester United will be the winner of this match
De Bruyne and Rodri are like players who play an important role in Manchester City and it is proven that when these players are not present on the field to compete, the club's performance decreases, such as the defeat against Arsenal because Rodri was not allowed to appear because he received a previous red card and from this situation it is very clear The composition of Manchester's players will be perfect if De Bruyne can recover quickly and appear again with Manchester City.
Manchester United may still have a chance to win because they appear at home, but in my opinion that will not happen considering that Manchester United has injured players so it is very difficult to beat Manchester City, but if it ends in a draw I can call it Erik Ten Hag successful in providing change.