Wine is a safe and open-source virtualization solution that allows to run Windows based applications on Linux and the applications on Wine run in a virtualized environment which won't affect the applications that run on the real Linux host system. I believe windows based malware won't impact the host of the Linux system as Windows malware are built in a way that they can affect Windows based users only.
The files and the whole Kernel module of Windows operating system is changed from Linux and that's another proof that Windows viruses and malware won't be able to penetrate Linux operating system. However, it's always recommended to avoid installing any application on the systems where someone saves his/her Bitcoin. Just don't be paranoid by such thoughts the Linux is a safe operating system and Windows malware can't harm it at all.
Please do research before posting.
Virtualization? Wine website clearly state it's compatibility later,
Wine does not perform sandbox at all,
7.5 How good is Wine at sandboxing Windows apps?
Wine does not sandbox in any way at all. When run under Wine, a Windows app can do anything your user can. Wine does not (and cannot) stop a Windows app directly making native syscalls, messing with your files, altering your startup scripts, or doing other nasty things.
You need to use AppArmor, SELinux or some type of virtual machine if you want to properly sandbox Windows apps.
Wine doesn't protect you from malware either,
7.4 Is Wine malware-compatible?
Yes. Just because Wine runs on a non-Windows OS doesn't mean you're protected from viruses, trojans, and other forms of malware.