Pep Guardiola was very unlucky during this season in Manchester City.
We know Kevin De Bruyne was one of the most important players in Manchester City but this player was injured hard at the start of the reason which damaged the whole team.
Now while we are on FIFA day, Ederson and Mateo Kovačić both are injured and this is bad news for Guardiola because they are going to have hard games against Tottenham and Liverpool soon.

I don't think what the unlucky factor from Pep Guardiola in this season behind result achievement won Premier League, FA Cup and UEFA Champion League trophies last season. Pep Guardiola is smart coach and he manages well with the same level between regular and substitute players, there are not problem with how many players are injured because Manchester City keep dominance in Premier League. For Kevin De Bruyne injured can replace well by Rodri and Mateo Kovacic, but international break out made Ederson and Kovacic have absent due injured still have many players will replace their position with the same level perform.
In my opinion, Pep Guardiola is not manager with depend on one player typical with his reputation when injuring Kevin De Bruyne at the first Premier League started but Manchester City keep dominance on the first standings place.