This will become a big problem when several important players experience fatigue which results in fatal injuries. Inzaghi also has to rotate his players in matches that are not too tough, but he has to see the right timing so that they don't lose. The second half of the season will be even busier because if they manage to qualify for the next phase in the Champions League then the matches there will be much tougher because they will face much stronger teams. The real worry will occur in the second half of the season because coaches will not be able to rotate injured players because they may not have suitable replacement players.
Being runner-up in the previous season definitely targets winning the Champions League this season and this is not an easy job because if Inzaghi fails to take advantage of the opportunities that exist it will have fatal consequences. Because Inter Milan could lose the opportunity to compete for the Scudetto or win the Champions League.
Inter Milan, a strong team in the Italian Serie A league has for themselves so much work to do regarding keeping themselves in the title race both league wise and tournament wise, the Italian league has some competitions in it and Inter Milan has to level up to these tasks, as well as level up to the task in the Champions league where there are even bigger competitors,
player rotation is welcomed as just single set of players can't do it all for a team.
A balance needs to be found, you can't overwork a player and expect positive outcome from every game, they're not robots, they need some sort of rest in between or else they'll be destabilized, they are a team envisioning the UCL title and they've actually got what it takes but they just have to put in extra work and effort.