It’s hard to say for sure because for really good teams, failure acts as an additional motivator. Aston Villa are consistently good (for their status) and for example last year they finished 7th while Tottenham 8th. In the upcoming game, Tottenham have the status of favorites, but their advantage is tiny and can only be attributed to the fact that Tottenham is playing at home:
2.32 - 3.80 - 2.82
Home or away doesn't matter. We must also remember that totenham was also missing lots of players too. Aston villa could take it as opportunity that shall be used as a way to win the game. It's not yet clear whether son will able to play against villa or he will absent due to the injury. There have been many speculations if he will out for months till early of next year due to the injury during international break.
Emery really needs three points. Aston villa just need to play used low block strategy, that's enough to give pressure to the totenham's players.