Every club must have key platers that the tean depends on and when those players are not present in any of their matches, it will be noticed because the tram performance will drop. Gundogan and De Bruyne contributed a lot to Manchester City success last season and since Manchester City is lacking these two players, it will affect their performance in reaching the finals.
Real Madrid still have hope that Vini will be back to his top form after some time, we could see this in their previous match in their domestic league where these two players Vini and Rodrigo scored tow goals each. Bellingham is doing great and I don't think that he will not be able to bring out his best performance as he has already shown the world that he is having a wonderful time in Real Madrid with the way he performs his dying minutes magic goals. Kross is doing well only if he has injury that it will be a problem for Real Madrid. From the look of things, I think that Real Madrid has a better chance of winning the league than Manchester City.
For Manchester City, they've got players that are key to them, although the team are good but there are some leakages in the team RN as a result of De Bruyne and Gundogan's absence, yes they still have an upper head in the contest but the team would best be in their top form when these two are present. Not loosing hope in them, they can still do the City magic.
For Madrid, Vinicius' injury is going to be responsible for his absence in subsequent games for a while, hoping that he'd be back on the pitch soon, Madrid has to find a replacement for him, one who's able to some extent match his capacity of else the leakage will be felt more, both Madrid and City are teams without an issue of having good replacements for an absent player, they have adequate skill squad who are young and vibrant and eager to deliver.