Real Betis this season has only been quite good in their defense. But in building attacks I think Real Betis will not be too dangerous for Real Madrid's defense. Because I see their squad is not very good at building attacks. Indeed, Real Betis has had more draws this season, with 15 matches we can see that Real Betis has achieved 7 draws. Which means almost half of all matches are draws for Real Betis. Honestly, I don't know whether this is a good thing or not. But yeah, Real Madrid can't be careless in this match. Because Real Betis, which has a fairly strong defense, and could build a quick counterattack and overwhelm Real Madrid.
But I'll probably still bet on Real Madrid. Because I see that Real Madrid has many advantages over Real Betis this season. So I think Real Madrid will win even if only by 1 or 2 goals.
Real Betis dominance with defensive and not offensive regarding with their goals winning ratio from 15 matches in La Liga, Real Betis goals scored productivities dropped drastically than other La Liga teams on the top six standings position. Scored 18 goals of 15 matches is not good achievement for Real Betis with wining ratio every match 1 or 2 goals and have one winning match above 3 goals against Valencia. I think difficult capital for Real Betis upcoming match against Real Madrid have more aggressive when attacking counter.
Real Madrid have more solid with defensive by conceded 9 goals and success scored 33 goals of 15 matches, with home match seems Real Madrid more favorable team than Real Betis on matchday 16.
Real Madrid do have better statistics and only conceded 9 goals without Courtois and Militao who are still absent due to injury, of course that is a fantastic result. I didn't expect Real Madrid to be this strong in defense and the appearance of Kepa and Lunin, who often rotate, has so far succeeded in keeping Real Madrid's goal from conceding many goals. This will also be a very impressive match for one of the former Real Madrid players who currently plays for Real Betis, namely Isco and playing against the former team he played for for many seasons will also be very meaningful in this match.
Apart from that, in general it is certain that Real Madrid will win even though this is an away match for them and the possibility of Real Betis winning is very slim because Real Madrid will do everything to maintain their top position from Girona.