I think this week will end really badly for Manchester City. Because I believe Liverpool, Arsenal and Aston Villa all are in a situation to be able to win their games this week. Liverpool can win against Manchester United home easily while Manchester United are bad at defending. Arsenal should be able to beat Brighton home as well.
Aston Villa are playing an away game against Brentford but Brentford are really bad this season. They were able to win only once on their last 5 game weeks in the league. I don't think they can hold off Aston Villa from winning another game.
Yes, Man City lost points where they should have earned them... Arsenal and Liverpool can really widen the gap in the standings... As for Aston Villa, I think they are really favourites to win against Brentford... But Aston Villa have a bad away record against Brentford... I think they might draw...
The performance of Manchester City has deteriorated drastically. Do not think anyone actually expected this performance from them. And let's also remember that all the other teams that are ahead of them, all three have played one match less compared to them. So now the gap in terms of points can actually be much bigger than it is right now. Manchester City better not lose any more upcoming matches. Otherwise, they will not be able to defend the English Premier League title successfully.