With the current situation, it is very difficult for Napoli to maintain their situation as the current defending champions.
Napoli is currently still very difficult to maintain its current consistency and performance even though there have been several improvements including the change of coach that has occurred but indeed this is still a fairness when talking about the Scudetto in Serie A.
Until now since the last few seasons the club that won Serie A has never been able to go back to back to get the Scudetto after prime Juventus until the 2020 season until now no one has been able to last for several seasons for the Scudetto including Inter, Milan and Napoli who took turns every season in the last 3 seasons.
Napoli chances are now only possible to be in the top 4 and must try to appear there because it would be very bad if they failed to qualify for the Champions League next season after previously winning very convincingly.
Napoli have lost several important matches in Serie A and that has made their chances of retaining the championship increasingly slim. However, because this is mid-season and the UCL schedule requires Napoli to work harder and save the energy of their players. Choose to focus on the UCL competition or try to improve their performance in Serie A. There is no choice for Napoli now but to focus on the Domestic League, after all they still have the same time and remaining matches as the top teams. A minimum of 4 or being able to finish in 3 is already a good opportunity. Competing with Bologna is Napoli's main target at the moment, for Mazzarri I hope he can improve the club a little because since his arrival there has been nothing more interesting to show to the fans who still haven't moved on from Spalletti.
Actually looking at what they did especially after relinquishing the Italian Cup then the focus must be on both although it's still very risky for them but i think they will still try to appear in Serie A and the Champions League.
The match against Barcelona in the round of 16 is actually a replay of the Europa League 2 last season and I think the similarities are still there because both clubs now still can't improve themselve well this season.
Barcelona still have the advantage and will definitely be favored but the match is still quite long and there is still enough time for Mazzari to be able to strengthen further the situation of Napoli now especially maybe some changes in the transfer window which will open soon.
On the other hand for Serie A also now their task is still very heavy because even if in the end they are not able to compete for the Scudetto but they must still try to be in the Champions League zone next season.