I think this is something that no team wants. Injuries to key players have a very negative impact on the team's performance, especially if it is an elite level competition such as the Champions League. This is the same as the injuries to Haaland and Kevin De Bruyne at City which will cause their performance to decline drastically. Inter have to face Atletico which is of course a difficult match. It will be interesting to see how Inzaghi will strategize to deal with this problem.
All teams manager have prepare with their squad for facing bad thing exactly main players injury, its very important how to manage teams keep balance level performance between regular and reserves players. I think Simone Inzaghi have alternative scheme when Lutaro Martinez get injury because still has Marcus Thuram with performance almost on the level with Martinez.
Learning from Pep guardiola when De Bruyne injury can manage well Manchester City performance in champion league by giving chance to other player fill in attacking midfielder and give good contributing help Manchester City qualify to of 16 round.
A player like Kevin De Bruyne should also be sold out of Manchester City, he be picking all of these injuries and it's been affecting his game and also his value of and on the pitch. He should be sold out now when they have his value high. A move to one of the Saudi Arabian Premier League would make perfect sense honestly.
Secondly should be Recce James, he's already had too much injuries, Chelsea should sell him off and make good profit from his sale. Both Real Madrid and Manchester City are both after him. They fail to do that and he'll have no value in the nearest future. Pep Guardiola should already lining up names who could possibly replace him.