I think the match will be much easier because Newcastle is not strengthened by some of its core players so Newcastle's strength will definitely be much weaker than usual. Liverpool will definitely play for victory because they have the ambition to maintain their standings and victory is a must for them in this match.
Liverpool have never lost at Anfield and everyone knows that, Newcastle also didn't play with their key players of course the betting market also gives high odds on Newcastle compared to Liverpool, I wouldn't take the risk in betting on this match considering Liverpool seems to really want to win. get the full three points and solidify their position at the top of the current standings. I'm sure Liverpool will win against Newcastle today.
If it applies to this season alone then I will agree with you a little as to the fact that Liverpool has not lost at Anfield, last season they lost a few games at Anfield and this season it's possible they could still loose at home but I'm not seeing that with this game against Newcastle so it's very possible they will maintain this record even after this game.
Liverpool remains my favorite for this game but then I will still keep an open mind to the possible outcome of this game, I have seen in recent time what have happened to big teams across Europe a d I can't tell when or if such fate will befall Liverpool so I wouldn't at this point exercise certainty even knowing how much Liverpool wants to win this game and strengthen their position at the top so that they will be able to give some good attention to Europa without fear of dropping down the table back at the premier league. It's very possible things could turn around on the pitch but considering that Liverpool has got the home advantage and the importance attached to this match, there's great possiblity they will win this game.