There is a matchup between Leipzig and Real Madrid as well. Real Madrid are clearly the favourite side of it however we might see some good resistance from Leipzig especially in Germany. The first game is there as well by the way. Even getting a draw would make Leipzig happy I assume because they are facing one of the title favourites.
At the end of the day Carlo Ancelotti's Real Madrid should be able to show their quality by a solid win at Santiago Bernabeu. Leipzig don't have the capacity to eliminate such team after the group stage. It isn't like the group stage anymore. The favourites take it even more seriously after that stage ends.
Everyone will predict that this match will belong to Real Madrid and Leipzig certainly understands this very well so they will be able to play without pressure so they can continue to put pressure on their opponents, especially in the first match.
The match is still over a month away so Leipzig can prepare themselves well even though there will be changes to the current odds it doesn't look like it will be much different where Real Madrid will get quite attractive odds in the match around @1.85-@2.00, but bet on yes both teams to scores, In my opinion, would be better than choosing Real Madrid on the money line because after all Leipzig is not a weak team and the chance of holding a draw in the first match is for Leipzig.
Leipzig is not a weak team, but Real Madrid has a fairly high mentality when playing in Champions League matches.
It's realistic that Real Madrid's chances of beating Leipzig are quite big, if there isn't a big surprise then Real Madrid will get through the round of 16 without any significant difficulties.
Now the teams have started to carry out evaluations and in the January transfer market the teams will certainly start to improve to become even better, not only Leipzig but Real Madrid too.
I'm not underestimating Leipzig but they are not yet at the same level as Real Madrid.