What would happen if all Bitcoin is mined and all Bitcoin is lost?
I don't know for sure the kind of answer your expect to get from this question because it's a question that obviously answers itself, there was once upon a time in the human existence when there was no Bitcoin in existence and people did lived well and were good same will happen if Bitcoin is gone after it's existence. It's not in doubts how Bitcoin has helped some lives and aswell improved people's standard of living but then it still doesn't mean if it's not there people wouldn't look for alternatives.
But then I would like to take you OP this question what is it that will make all Bitcoin to be lost just like that, why did you think such can happen and is the possibilities you see that influenced such taught in you.