I don't think PSV will actually be that much of a problem for Dortmund. The problems will be coming after they pass the Round of 16. Sure, PSV has beaten some good teams to get in the playoffs but Dortmund was in the group of death in my opinion. They topped a group where everyone thought they would be the bottom team. In their group, there were AC Milan, PSG and Newcastle. Newcastle performed very well in the last season in the Premier League but this season they are underperforming. But PSG and AC Milan are no joke. And they beat both of them to become the table topper.
One mistake Dortmund will make at this stage of the UCL will have to be underestimating PSV and thinking they will be able to win them at ease probably because they seem to appear superior but then I believe PSV may give them a really tough game to play such that they may loose or draw the game if they are not at their best performance.
Checking back in their domestic league, PSV is really doing so well and at the top of the table with a very good margin ahead of other teams, I'm very optimistic about their performance because even at the group stage they were able to qualify at the second position with four points behind the team at the top of their group, PSV is very likely to get a draw in this game because recently Dortmund has not been of a very good performance enough to be sure they will be able to beat such a determined team but then both teams do not have so much of UCL experience so they can battle themselves out.