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IMO for now no one will doubt Manchester City in this match even though Copenhagen is one of the big clubs in their domestic competition but in the end they may not mean anything in front of Manchester City.
The current situation if we look at it as a whole i think Manchester City are superior in any case especially with the return of several players such as De Bruyne, Haaland and Doku then indeed this is a difficult situation for Copenhagen.
They struggled to qualify for the 16th round of the Champions League this time and were immediately faced with the defending champions so the best option that could be done was to try to get a draw in a match that was done with their defense to make the speculation different in the penalty shootout but in the end it was also not an easy thing to do because in the end we know that it will be very difficult to realize that when their opponent is Manchester City.
It could be said that Copenhagen needs a miracle to beat Manchester City, because we understand that the level of strength of the two teams is very different. Copenhagen was lucky to qualify for the round of 16 because United performed poorly, and it looks like City will finish this match easily. That doesn't mean there were no surprises at all, but the best thing the Danish representative could do was hold Pep Guardiola squad to a draw. As you said, the return of a key player like Kevin De Bruyne will certainly benefit Pep, his presence in the lineup will make everything easier.
I feel that City will have no difficulty in reaching the quarter finals, and maybe it will also be easy for them to reach the semifinals if they face a club that is not the favorite again. However, that is only a personal assumption, without underestimating any team in the round of 16. Because we understand that sometimes we lose our luck because we believe too much in our favorite team, we will take another look at the preparations of both teams ahead of mid February.