Vitalik Buterin's advice to avoid using more than 2x leverage in trading is wise. It helps manage risk in the highly volatile cryptocurrency market. It's crucial to distinguish between traders and investors, with traders using lower leverage for safety. Asset security in noncustodial wallets is essential. Leverage suitability depends on an asset's volatility, and high leverage can lead to liquidation, as seen with TRB's price drop. Responsible trading involves assessing risk tolerance and market conditions while prioritizing asset security and control.