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Don't use >2x leverage. Just don't.It is one of the things he listed as a financial advice. As a trader, what do you think about it? We set some money aside for trading and as for me I still use up to 2.5x leverage for bitcoin to open a long position...
I have not found information anywhere that Vitalik Buterin is engaged in trading, so I am skeptical of such advice. We know that there are different opinions on this issue, but we can only say for sure that if someone does not know how to trade, then he should not increase his losses using margin.