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In terms of experience, the three teams have different levels of experience in the Champions League and I think there will be interesting competition between the three teams this season in the Champions League. Moreover, with the return of Kevin De Bruyne to the Manchester City squad for the remainder of this season, there will certainly be a good incentive for the Manchester City team itself to compete again with other big teams in the Champions League, especially with the two teams you have mentioned.
Real Madrid, Bayern Munich and Manchester City do not have very strong opponents in the round of 16. This means that the three teams above are favorites to advance to the quarter-finals, and there they will get better competition for tickets to the semi-finals. The performance of each team in the domestic league so far is basically not the only benchmark for judging how good their chances are of qualifying for the quarter-finals. Player injuries, suspensions and players' physical fitness ahead of the match will certainly be something to pay attention to as well.
I agree that the 3 teams mentioned above are candidates who could be favorites to qualify for the final, but maybe they will meet more quickly in the next match, either in the quarter-finals or in the semi-finals, where in the end only one team will be left. There are many scenarios that will happen after the 8 best teams qualify for the quarter-finals, so we'll just have to wait and see how that happens.