Yeah, that's a no-brainer. It's the fight everyone wants. Maybe everyone except for Izzy. No one knows what's in his head, but if he's serious about getting the belt back, he cannot afford to have an extensive break, he'll be 35 in July. I think his confidence got seriously damaged after that loss to Pereira. He took his revenge but was not looking good in that fight and then Strickland came along and manhandled him for 4 out of 5 rounds.
Izzy doesn't really deserve the title shot, as he lost to Strickland, who got defeated by Dricus, so he should be having at least one more fight, but there are no better options right now, so things are stacking in his favour.

I don't think we'll see two of them as the main event of UFC 300, that's probably too soon for Dricus, but then again, it could be the biggest payday in his lifetime, so he could go for it.