Yes, we can also consider lost Bitcoin to be a big factor because experts are estimating at least 2.5 million of Bitcoin to be lost. It is difficult to predict any amount of lost Bitcoin but we have Satoshi's coins, we have so many stories from early Bitcoin people who have lost access to private key or are searching private keys in waste disposal areas like someone from England. He's searching his private key in a waste disposal factory.
Much Bitcoin is lost.
And it will only increase. Maybe not big amounts anymore but it can happen very fast to lose access to our coins.
Or when more people will have Bitcoin and send it, a small amount might be left at an address or forgotten, it can always happen.
Storing our private key safe is still very difficult because it happens frequently for people to lose it.
Lost Bitcoin will only increase and will reduce all circulating Bitcoin.
It is normal that some bitcoins will go out of the control of people or investors, many people die with bitcoins in e-wallet and those bitcoins cannot be recovered without that person, I think it is normal that those bitcoins are lost. The more bitcoins are spread among investors, the higher the price of bitcoins will increase. We want Bitcoin to spread to more investors and increase the amount of holders, so if Bitcoin is held like this now, then the price of Bitcoin will go up a lot later. It is best to keep our bitcoin wallet keys with own people so as not to get lost.
Surely some people will lose their Bitcoin upon death, especially those who have not worked out a way of transferring their Bitcoin to heirs and people the care about. It is therefore important to work towards retirement and handing over when we get to certain stage in life. There have been several fine suggestions about this matter in this forum such as the threads below:
If you read through the discussions, you will see other suggestions by reputable members of the forum and I'm confident you will get the answer seek.