It is normal that some bitcoins will go out of the control of people or investors, many people die with bitcoins in e-wallet and those bitcoins cannot be recovered without that person, I think it is normal that those bitcoins are lost. The more bitcoins are spread among investors, the higher the price of bitcoins will increase. We want Bitcoin to spread to more investors and increase the amount of holders, so if Bitcoin is held like this now, then the price of Bitcoin will go up a lot later. It is best to keep our bitcoin wallet keys with own people so as not to get lost.
Actually it all depends on the investors planning because I see no reason an investors Will invest very huge on Bitcoin without a plan of transferring his investment to his children if he sees that anything could happen to him because of his health challenge, however we no that death is inevitable and could happen on any form, so perhaps since an investor has a plan of holding his Bitcoin for a very long time perhaps he should be able to carry most of his children along even if he doesn't give him access to his Bitcoin investment but his children should be carried along by knowing what Bitcoin is all about and then he could possibly drop a voice record that explains everything about his investment and details involves to his lawyer that if something should happen to him he should take the voice record to his family, so perhaps with that even if someone is gone his family could still be able to continue his legacy. Besides every purpose of investors is to invest for his future and that of his family so there is every chance that such investors may not likely lose his investment if he is gone because before it will get to that extent he most have drawn a back up plan that enable his family have access to his investment while he is gone.