The Inter match is also important because both the players and the technical staff must be prepared in the best possible way in matches with a very high level of difficulty. Therefore, the Inter match will be a good match for De Rossi, not for criticism, but to see his preparation for big matches. Inter has built a very good squad both last year and this year and they are running from success to success. If De Rossi plays a superior game in that match, then he will deserve praise.
De Rossi's reputation will even increase rapidly if the AS Roma vs Inter Milan match results in a draw. So in this match De Rossi will have two advantages. If Roma wins then De Rossi will get a lot of praise and if AS Roma gets a draw then De Rossi will still be appreciated. And if AS Roma loses then De Rossi will still be forgiven and will not be blamed at all. 
So the result of the AS Roma vs Inter Milan match will not be a pressure for De Rossi. Because even if AS Roma loses then everyone will understand that Inter Milan is a great team this season and it would be very natural for Roma to lose. And De Rossi is also still new as AS Roma coach so he still needs more adaptation. And everyone definitely understands that.