When I look at the matchups I think that the most difficult to predict result can the Napoli v Barcelona and Inter v Atlético Madrid. I mean theory there are favourite of this matches which is Barcelona and Inter. You know Barcelona are having really tough days and Xavi even announced his parting ways with Barcelona this summer. Napoli could make a surprise. Also, Atletico Madrid plays very consistently in Laliga as well as Inter Milan in Serie A, so these two clubs will play carefully, aggressive and defensive, play both of them are equally good.
Agree. The match between Napoli and Barcelona will be difficult to predict because both the teams are in bad performance this season. It is very different from the last season, I can guarantee Napoli will defeat Barcelona if Napoli is still managed by Luciano Spalletti. It is very sad that Napoli begins to be a mediocre team after Luciano Spalletti left the team.
For the match between Inter Milan and Atletico Madrid, I think Inter Milan should be more superior. Inter Milan has more solid players in each line. Inter Milan has strong defenders and they have a great striker like Lautaro Martinez. They were also the finalist of UCL final in the last season, they still have the same squad and the same coach like the last season. So, the chance to reach the final round again isn't very different from the last season. I'm sure Inter Milan has a better chance to beat Atletico Madrid.