The clash between Inter and Atletico Madrid is going to be quite interesting. 
Inter are favoured at Giuseppe Meazza in the first game of course. But I don't see a big difference between these two teams. The only difference seen is their positions in their domestic leagues at the moment. But this would be really misleading while comparing these two teams.
Because maybe Atletico Madrid aren't in any title competition in the La Liga but they are still a very strong team now. They did a really good job against Real Madrid in a game recently as well. I expect a solid resistance from them in the first game even if they lose. My score prediction is like a 1-0 or 2-1 win by Inter.
Inter are favoured at Giuseppe Meazza in the first game of course. But I don't see a big difference between these two teams. The only difference seen is their positions in their domestic leagues at the moment. But this would be really misleading while comparing these two teams.Because maybe Atletico Madrid aren't in any title competition in the La Liga but they are still a very strong team now. They did a really good job against Real Madrid in a game recently as well. I expect a solid resistance from them in the first game even if they lose. My score prediction is like a 1-0 or 2-1 win by Inter.
My estimate is that in this match, Inter will be the favorite, playing at home. Inter also has a good record when playing their matches at their home ground, San Siro, regardless of their performance in their Domestic League. while Atletico, this team is basically quite strong. however, based on their record in away matches, Inter is slightly better if we refer to their performance in their domestic league. plus, Simone Inzaghi is a clever coach. that's why he was able to bring Inter to become one of the finalists in the Champions League last season. that doesn't mean that Atletico Madrid doesn't have a chance to overthrow Inter at the San Siro. however, it will be very difficult for Diego Simeone's team to get full points at Inter Milan headquarters. but, just look at the real match when this round of 16 match is held. however, if we refer to the betting exchange, Inter has odds @1.95 and Atletico with @3.95. well, because this match still has a time lag, the odds can change. there is no other choice but to wait for the battle between these two teams to win the title. It could be that what you predict has the potential to happen.