Real Madrid must expect to win the match. They are expecting to lead the table with a more comfortable points. However, some defenders of Real Madrid are injured, Ancelotti may have a problem to plan the defense line. Ancelotti only has Nacho Fernández for center back, he may put Aurélien Tchouaméni as the alternative for a center back. If Tchouaméni can perform well, I think Real Madrid may win the match.
I think Real Madrid's first thing to think about is not defense, they better think about how to score goals. Because Girona is not like other teams. They can defend very well and drive opponents crazy. Also, once they score a goal in a transition attack, the opponents disperse. There will be pressure on Real Madrid because they have to become champions, but there is no such pressure on Girona. It's still a miracle for many people that they even came here. While they play with the comfort of this, Real will play a match they must win. You may think that it doesn't affect the players much at this level, but match stress can sometimes reach very different levels.
It is wrong to thing for a second that Real Madrid could be thinking about their defense strategy. They are and they have always been a club that wanted to win all the titles possible. There has never been a title when Real Madrid had to say that they should be careful. They treated their opponents with respect, but the only goal was to win that title.