My prediction is that the very tight matches will be between Roma vs Brighton, Marseille vs Villarreal and Freiburg vs West Ham, while the matches that might be uneven are between Bayer Leverkusen vs Qarabag FK and Liverpool vs Sparta Prague.
The two favorite teams are very lucky to face teams that can be said to be weak in this competition, especially Bayer Leverkusen facing Qarabag, of course they will face a match that can be predicted easily, and in my opinion Roma is one of the teams that is less fortunate because they face Brighton, even though Brighton doesn't have much experience in this competition European league but they cannot be underestimated and they are quite a solid and productive team and this is a battle between two Italian coaches and Roberto De Zerbi looks more solid with his current squad and their chances are quite big to qualify.