I think Roma are quite likely to be eliminated from the Europa League quite early. Because Brighton are a really challenging opponent for them. You know how good Brighton were in the group stage as well. They have a squad including quite talented players. I must admit the drop in their form in the Premier League recently but they are still a big threat to Roma.
Roma are trying to get better after a manager change. However we saw how bad they were against Inter for example. They aren't very good especially defensively when it comes to big games. Thinking Brighton have effective attackers I don't see their chance low at all.

Even in the first game, which will be held in Rome, Roma will only be a formal favorite:
2.45 - 3.28 - 2.80
Despite the fact that Brighton performs worse in the Premier League than Roma in Serie A, the difference in the level of the leagues apparently has an effect. The Premier League is rated much better. It seems to me that under Mourinho, Roma would have had more chances to win against Brighton, since in closed football there are always chances, but now, most likely, we will see BTTS in both games, and Brighton will go further.