I think Roma are quite likely to be eliminated from the Europa League quite early. Because Brighton are a really challenging opponent for them. You know how good Brighton were in the group stage as well. They have a squad including quite talented players. I must admit the drop in their form in the Premier League recently but they are still a big threat to Roma.
Roma are trying to get better after a manager change. However we saw how bad they were against Inter for example. They aren't very good especially defensively when it comes to big games. Thinking Brighton have effective attackers I don't see their chance low at all.

This is indeed hard match for Roma because during group stages Brighton performance is far better compared to them but we shouldn't be forget because Roma is the finalist of last season so i am sure they will not be easily to beated especially Roma under De Rossi has been showing significant progress and the latest is Roma can able to beat Torino yesterday in Serie A and about Brighton this team was unstable in Premier League but for Europa League and FA Cup Brighton still able to managed their consistency because in Europa League Brighton can advances to the round of 16 and in FA Cup Brighton can reach to 5th round
I have to says the chances for Roma and Brighton is 50:50 which mean both teams has equal chances to qualified and first match will be held in Olimpico stadium which is Roma home ground and if Brighton can able to get at least draw result at there i think second leg will be more easy for Brighton but i have been notice on Europa League under Mourinho Roma has fantastic records at their home because since October 2022 in this competition Roma still unbeatable during playing at their home so these records makes me thinking there is possibility for Roma to win this match moreover Roma under De Rossi can playing more attacking