I don't think difficult to predict the winner between AS Roma vs Brighton Albion, in this season Brighton have dropped perform in Premier League and current standings dropped until 7th place. I don't think Brighton will be favorite time for winning against AS Roma with consistency performance in domestic league after sacking Jose Mourinho and replacing by Daniele De Rossi.
AS Roma have much experienced playing in Europe League than Brighton Albion become their first appearance this season and AS Roma performed last season success lead until final round.
Playing as home match on first leg, I think AS Roma have bigger opportunity for defeating Brighton Albion exactly with their attacking line on top perform with Paulo Dybala and Romelu Lukaku had impressive performance.
I don't think so, every team has different motivations in every competition they participate in and I see that in terms of strength the AS Roma team is not that different from Brighton so these two teams still have the same chance of winning the match.
And we cannot determine the performance or results of a team in its domestic league for the Europa Leeague match they will play.
We can see that Roma struggled to beat Feyenoord and there was even a bit of a luck factor because the result of the pinati match was determined after the two teams played a game.
So against Brighton I think the same way, this will be a tough match and both teams have the same possibility of getting through to the next round.