I agree that the match between Roma and Brighton will be difficult to predict as both teams have similar strengths. However I believe that Roma has the edge in terms of experience and recent improvements under De Rossi coaching. Their performance in the Europa League and reaching the final last season shows that they have the ambition and mentality to succeed again this season. I think Roma will have a slight advantage in this match. So let's see.
I don't think difficult to predict the winner between AS Roma vs Brighton Albion, in this season Brighton have dropped perform in Premier League and current standings dropped until 7th place. I don't think Brighton will be favorite time for winning against AS Roma with consistency performance in domestic league after sacking Jose Mourinho and replacing by Daniele De Rossi.
AS Roma have much experienced playing in Europe League than Brighton Albion become their first appearance this season and AS Roma performed last season success lead until final round.
Playing as home match on first leg, I think AS Roma have bigger opportunity for defeating Brighton Albion exactly with their attacking line on top perform with Paulo Dybala and Romelu Lukaku had impressive performance.
Roma and Brighton are basically not much different in their respective domestic competitions. Brighton has collected 39 points from 26 matches, while Roma has collected 44 points from 26 matches as well. I feel that both teams are equally strong and have the same chance of winning the match, so I don't think one of them is the favorite and the other is called weak.
There was a loss to a team deemed inexperienced in the end progressing to the next round surprisingly, that's often the case in the Europa League so Roma weren't really expected to underestimate Brighton. The first leg was played at the Stadio Olimpico, Rome, so Roma may be a slight favorite because they are playing at home.
I think Brighton can do a lot of damage to Rome because of his way of attack, Rome is weak in defense and Brighton has a very fast and powerfull attack, plus De Zerbi is Italian born and raised so he really know how Italian teams play.
But ROme still having some better players, lets see what win, stars or team work.
The squad depth of the two teams is different, there are also other differences that should not be ignored, namely the style of play of the two teams. These are the two interesting things about this fight, so neither will underestimate the other.