I think Brighton can do a lot of damage to Rome because of his way of attack, Rome is weak in defense and Brighton has a very fast and powerfull attack, plus De Zerbi is Italian born and raised so he really know how Italian teams play.
But ROme still having some better players, lets see what win, stars or team work.
I think Brighton is luckier in this matchup in terms of some facts. De Zerbi knows Italian football well and is a quality coach. On the other hand, his experience is better than De Rossi. He also knows how to motivate his players. When we add the Premier League experience to this, a great team emerges. In my opinion, Rome's chances are very difficult. They must play without mistakes and take advantage of every opportunity.