I agree that the match between Roma and Brighton will be difficult to predict as both teams have similar strengths. However I believe that Roma has the edge in terms of experience and recent improvements under De Rossi coaching. Their performance in the Europa League and reaching the final last season shows that they have the ambition and mentality to succeed again this season. I think Roma will have a slight advantage in this match. So let's see.
I don't think difficult to predict the winner between AS Roma vs Brighton Albion, in this season Brighton have dropped perform in Premier League and current standings dropped until 7th place. I don't think Brighton will be favorite time for winning against AS Roma with consistency performance in domestic league after sacking Jose Mourinho and replacing by Daniele De Rossi.
AS Roma have much experienced playing in Europe League than Brighton Albion become their first appearance this season and AS Roma performed last season success lead until final round.
Playing as home match on first leg, I think AS Roma have bigger opportunity for defeating Brighton Albion exactly with their attacking line on top perform with Paulo Dybala and Romelu Lukaku had impressive performance.
Not entirely sure about it as much as you are, feels like there could be something that may change, and while we do look at it like Roma should be getting a win because they are getting better, Brighton has some amazing young talents that they could use as well.
So I do not see this to be something good, I just see it as a tough matchup, I believe that Brighton has a chance to win as well, so there shouldn't really be anything that would confuse them all that much. I will not be betting on either game to be fair, because I am not sure what's going to happen, I can just assume what may happen, but I am pretty sure that I would be wrong and there is no reason why I should be accepting something like that to be possible for me.