I agree that the match between Roma and Brighton will be difficult to predict as both teams have similar strengths. However I believe that Roma has the edge in terms of experience and recent improvements under De Rossi coaching. Their performance in the Europa League and reaching the final last season shows that they have the ambition and mentality to succeed again this season. I think Roma will have a slight advantage in this match. So let's see.
I don't think difficult to predict the winner between AS Roma vs Brighton Albion, in this season Brighton have dropped perform in Premier League and current standings dropped until 7th place. I don't think Brighton will be favorite time for winning against AS Roma with consistency performance in domestic league after sacking Jose Mourinho and replacing by Daniele De Rossi.
AS Roma have much experienced playing in Europe League than Brighton Albion become their first appearance this season and AS Roma performed last season success lead until final round.
Playing as home match on first leg, I think AS Roma have bigger opportunity for defeating Brighton Albion exactly with their attacking line on top perform with Paulo Dybala and Romelu Lukaku had impressive performance.
AS Roma are in better shape than the Europa League. Brighton are not in better shape currently, even in the Premier League. They have been experiencing bad times, although I cannot guarantee AS Roma winning as I don’t know what the match will be for them, but I’m sure they will deliver their polling unit positively because they have been consistently playing in the league this season, and obviously Brighton are even better than them in any way as long as the Europa League is concerned this season. Although for me, I cannot predict these matches as you just confidently gave AS Roma winning, but I’m sure they will do well.
Furthermore, AS Roma are going to play at home, so playing in front of their fans will give them more motivation to do more than we are expecting from them, and as it’s now, they were performing well last season, so they will do their best to see that they get the same thing or even the title this season. However, let’s wait and see how Roma are going to perform against Brighton.