Re: Bitcoin was created to reform money and provide financial freedom
But serious investors invest serious money which most people wouldn't trust to physically hold in their hands where it can be lost or stolen. Most people invest their life savings in an account in their name so it can't be taken from them no matter what.
Right. So, serious investors are given two choices. Either ignore this financial and technological innovation, or invest with that risk. I believe that a serious investor can spend a few of their valuable hours on setting up a wallet and maybe even for having some extra security, educate themselves about multi-sig. They are not investing in "technological innovation", they are investing in an instrument they think will go up in value in the short run. I can almost guarantee that most big investors don't give a crap why it's going up--they just invest because they think it's going up.
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And they're fine with it, because they are secured. If a bank goes bankrupt, the state will protect its customers. But if a centralized exchange goes bankrupt, customers get no cent back. I expect from serious investors to have this knowledge and not blindly trust a business with their money.
Yes, they know that, and look for institutions that have good infrastructure and processes, like any major bank has. And there are insurance companies involved securing the investment in some cases based on processes like 27001 compliance. I guarantee you that a line investor at Goldman Sachs doesn't have his firm's billion dollar investment in Bitcoin locked in the top drawer of his desk.
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(My article, The Anon Paradox, points out the seeming paradox between wanting anonymity for "small" amounts of money like the cash in your wallet versus "big" amounts e.g. your savings, car or house wherein anonymity is actually a bad thing for most people).
It's good that we have some new controversy over the space. I'll read your article once I find the time. And, if I haven't told you already, welcome to Bitcointalk! 
Thank you very, very much. This is a most excellent forum to discuss ideas, which is actually unusual for the internet these days.