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It's true, Barcelona immediately felt a big impact on their game after De Jong and Pedri were withdrawn not long after De Jong left. The good news is that they didn't lose to Bilbao because the home team didn't play as well against Atletico Madrid, but the bad news is that the two midfielders will miss the second leg of the Champions League against Napoli.
Before the second leg of the last 16 of the Champions League, Barcelona basically has one important match against Mallorca at the Lluís Companys Olympic Stadium. Barcelona certainly hopes for the best before the Champions League match, so maximizing the existing players is the last option Xavi has for his team.
I don't want to say much about Barcelona because I don't think they are very serious in La Liga this season. There are many things that have affected their performance this season and these things have not been able to be fixed until now. The team doesn't seem to have much motivation to win matches and that has been the case all season until Barcelona has never been able to improve its position in the standings.
Player injuries are the most influential thing on the team's overall performance, but the very bad financial conditions mean that Barcelona is forced to use young players who more or less have not improved much. Fermin Lopez, Lamine Yamal, Pau Cubarsi, and several other easy players can help in some matches, but their young players tend to be unstable and cannot always be relied on. But because of Barcelona's poor performance this season, Real Madrid should be grateful for that because they have no obstacles to winning the title this season.