I hope that both teams can field their best squads, so that we can watch the match run with high tension. The atmosphere will be very different from other matches, because the Man City versus Madrid match can be considered an early final. It is true that it is very difficult to predict the final result, because both teams are strong candidates to win the Champions League trophy this season. The injury factor will indeed play a role in each club chances of winning, losing key players is a big loss for Pep Guardiola or Ancelotti.
Madrid may have a slight advantage in the first leg because they will act as hosts, Ancelotti will use all the resources he has to achieve revenge. On paper, both teams have the complete attributes to beat each other regardless of home or away matches, this is where it is difficult to predict the final result of this match. Furthermore, I think whoever can emerge victorious in that match and advance to the semifinals will have a big chance of winning the trophy this season.
This is a match between two of Europe's top teams at the moment, a match full of prestige and revenge, of course both teams will field their entire best squad and use all their best qualities in this match.
Both teams are aware that this is a very, very difficult match, so there is nothing to be underestimated here.
This is very possible because from the start Real Madrid and Manchester City were quite the favorites to win the UCL title this season, but unfortunately the meeting between the two teams happened too quickly.
Playing home or away may have a slight influence but it is not that significant and I think everything will be quite fair for both teams.