I don't know for sure whether Kevin de Bruyne can be used against Arsenal or not, but if he can be used, of course it will be an advantage for Manchester City because they will be strengthened by players they really rely on in midfield. He is one of the players who has had a lot of positive impact on Manchester City's game, and in fact they also still have many players who contribute.
Regarding Arsenal's chances, they still have an open opportunity to get points from this match. However, keep in mind that their current opponents are not an ordinary club even though there are several players who cannot be played. As hosts, Manchester City will also not allow anyone to go home with points, including Arsenal. They are still the main favorites in this match to win the match. But what is clear is that I hope we can be presented with an interesting game that these two clubs can show. I want to see them appear to attack each other to make the match more interesting.
There is no information about De Bruyne yet, let's hope that the injury is not so serious. It became known that Walker will be able to play against Arsenal, the injury was not serious, this is good, but with Ederson everything is not so good, according to preliminary forecasts he will be able to return to the game in mid-April, so he will most likely miss the games with Arsenal and Aston Villa, and also possibly the first game with Real Madrid in CL.
Manchester City seemed to experience a serious disaster at the end of the season and they had to lose several key players ahead of a crucial match. It seems that not only De Bruyne, Kyle Walker and Ederson but Akanji and Stones were also hit by the same injury. But if it is true that Kyle Walker can recover more quickly, of course that will be quite good and at least their defense will not be as weak as we think.
I think against Arsenal they have to be in really good form and Manchester City have to be able to overcome that later. Apart from that, the match against Real Madrid in the Champions League is another important thing for them to advance to the semifinals. But if when the time comes there has been no progress from the players then Pep Guardiola will have to re-strategize so that the carelessness he is worried about can be resolved properly.