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There is no information about De Bruyne yet, let's hope that the injury is not so serious. It became known that Walker will be able to play against Arsenal, the injury was not serious, this is good, but with Ederson everything is not so good, according to preliminary forecasts he will be able to return to the game in mid-April, so he will most likely miss the games with Arsenal and Aston Villa, and also possibly the first game with Real Madrid in CL.
To be honest, I didn't realize that several of Manchester City's main players had recently been injured, so if that were true then of course Arsenal's chances of winning would be even greater. Manchester City doesn't feel special without De Bruyne in their squad, and neither does Ederson. These two players are needed in the Manchester City squad because of their influence, but if they are absent due to injury, of course Manchester City will have to work extra hard later.
I know Manchester City still holds the advantage because they are playing at home, but without De Bruyne's presence the team's performance is difficult to expect. Pep Guardiola will have to be extra careful when hosting Arsenal at the Etihad and he may need to consider the worst consequences of being without his two best pillars in the main line-up.