There is no information about De Bruyne yet, let's hope that the injury is not so serious. It became known that Walker will be able to play against Arsenal, the injury was not serious, this is good, but with Ederson everything is not so good, according to preliminary forecasts he will be able to return to the game in mid-April, so he will most likely miss the games with Arsenal and Aston Villa, and also possibly the first game with Real Madrid in CL
If De Bruyne can't play, I think Man City's attack will decrease a little more because I see De Bruyne is the brain of the attack regulator for Man City. When he can't play, Man City's game patterns will definitely change a little and too many players who cannot play will be quite detrimental to Man City. I hope the injury is not too severe and he can play for the big match because when they lose points in this match it will make them a little difficult to pursue champions.
If this happens Arsenal will be a little more profitable and they can play more openly and not too worried about Man City's quick attack patterns. Despite losing some important players in Pep Guardiola's squad will not make their game change completely but Arsenal can be a little easier to target the draw.